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Apolipoprotein E (APOE)

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Apolipoprotein E (APOE) as a fat-binding protein is highly expressed in astrocytes and microglia, and its isoforms differentially affect cholesterol metabolism and inflammatory responses

Recent studies have suggested that apolipoprotein E (ApoE) isoforms, which strongly influence Alzheimer's Disease (AD) risk and regulate tau-mediated neurodegeneration, differentially affect the gut microbiota
Seo et al. 2023 Science 379: