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Alzheimer's disease (AD) & Apolipoprotein E (APOE)
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Contents
The study explores the initiation of Alzheimer's disease (AD) through the seeded growth of pathogenic protein aggregates. It highlights the genetic link of sporadic Alzheimer's disease (AD) to apolipoprotein E (APOE) and genes in microglia associated with immune, lipid, and endocytic functions. Researchers developed a transgenic mouse model expressing HaloTag-tagged APOE to purify APOE biochemically. They discovered fibrillary aggregates of APOE in mice with amyloid-beta (Ab) amyloidosis and human AD brains. These aggregates, which bind to beta sheet-binding dyes, trigger Ab amyloidosis in microglia's endo-lys…
References (Sources)
- A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease
- ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo
- Disease-associated astrocytes in Alzheimer’s disease and aging
- Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk
- High cholesterol level is essential for myelin membrane growth
- Lipoproteins in the central nervous system
- The role of APOE on lipid homeostasis and inflammation in normal brains