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Little attention has been given to the role of DNA methylation in immune responses against cancer. Methyl groups can be erased by ten–eleven translocation (TET) family proteins followed by glycosylation and replacement with an unmethylated cytosine
Methylation at CpG sites can also be recognized by methyl CpG binding ‘reader’ proteins such as Methyl-CpG binding domain protein 1 (MBD1) and methyl-CpG binding protein 2 (MeCP2)
DNA methylation also plays a key role in [cytotoxic T cell](brain:…