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Immunity & Polyamines

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Polyamines (i.e., putrescine, spermidine, and spermine) are bioactive polycations capable of binding nucleic acids and proteins and modulating signaling pathways.
Proietti et al. 2020 Trends in immunology 41: 1037

Recently, spermidine was found to exert protective effects in an experimental model of multiple sclerosis (MS) and to confer immunoregulatory properties on [dendritic cells (DCs)](brain://6n8EEQvO0E-2zESRYbLMJA/Dend…