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Polyamines / Polyamine
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Polyamines such as putrescine, spermidine and spermine are the metabolites of dietary arginine produced by host tissues and the gut microbiota. The rate-limiting enzyme in polyamine synthesis is ornithine decarboxylase (ODC).
Polyamine functions have been studied extensively in tumors, where they can promote cell transformation and proliferation.
Polyamines are capable to bind [nucleic acids](brai…
References (Sources)
- Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling.
- Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications
- Polyamines and Kynurenines at the Intersection of Immune Modulation
- Remaining Mysteries of Molecular Biology: The Role of Polyamines in the Cell
- Spermine differentially regulates the production of interleukin-12 p40 and interleukin-10 and suppresses the release of the T helper 1 cytokine interferon-gamma
- The gut microbiota, bacterial metabolites and colorectal cancer
- Understanding the Holobiont: How microbial metabolites affect human health and shape the immune systemReview