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Polyamine synthesis & Ornithine decarboxylase (ODC)
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Polyamines, such as putrescine, spermidine, and spermine, are synthesized from amino acids like ornithine and methionine. The process begins with the conversion of ornithine to putrescine by the enzyme ornithine decarboxylase (ODC), which is considered the rate-limiting step in polyamine biosynthesis. This step is crucial because it regulates the overall production of polyamines within the cell.
Schultz et al. 2019 Biochem J 476(14)…