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Polyamines such as putrescine, spermidine and spermine are the metabolites of dietary arginine produced by host tissues and the gut microbiota. The rate-limiting enzyme in polyamine synthesis is ornithine decarboxylase (ODC).
Polyamine functions have been studied extensively in tumors, where they can promote cell transformation and proliferation.
Polyamines are capable to bind [nucleic acids](brai…