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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

meRfi® AI Chat

Adiposity / Obesity & Childhood / Child

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In the United States, children have an elevated intake of saturated fats (Wang et al. 2018b Am. J. Clin. Nutr. 108: 868-877) and a high percentage of therapeutic antibiotic usage (Zetts et al. 2018 Pediatrics 141: e20174124). However, how concurrent exposure to an High-fat diet (HFD) and antibiotics alters the risk for childhood obesity remains unknown.
Shelton et al. 2023 Cell Host & Microbe 31:

An obesogenic Western-style HF diet perturbs the microbiota and elevates the risk for [metabolic diseases](brain://gaettDKt71SDbucTVdunyA/MetabolicDiseasesMetabolicDisorders…

References (Sources)

An early-life microbiota metabolite protects against obesity by regulating intestinal lipid metabolism
Shelton et al. 2023 Cell Host & Microbe 31:
Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome
Turnbaugh et al. 2008 Cell Host and Microbe 3: 213-223
Fighting Fatty Liver Diseases with Nutritional Interventions, Probiotics, Symbiotics, and Fecal Microbiota Transplantation (FMT)
Nobili et al. 2019 Adv Exp Med Biol 1125: 85-100
Review
High-fat diet-induced colonocyte dysfunction escalates microbiotaderived trimethylamine N-oxide
Yoo et al. 2021 Science 373: 813-818
Implication of gut microbiota in the association between infant antibiotic exposure and childhood adiposity/obesity and adiposity accumulation
Chen et al. 2020n
Nonalcoholic fatty liver disease in children
Manco et al. 2008 J Am Coll Nutr 27:667-676
Review
Outpatient antibiotic use and the need for increased antibiotic stewardship efforts
Zetts et al. 2018 Pediatrics 141: e20174124
Review

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12/16/2025

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Childhood obesity - Wikipedia