meRfi®-GM
Goblet Cells
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Contents
Damage of Goblet Cells causes loss of IEC integrity and permits the translocation of gut microbes and all gut antigenic load (metabolites, peptides, and proteins) into the submucosa, lymph nodes, and bloodstream.
This consequently enhances the production of pro-inflammatory cytokines and stimulates the [GvHD](brain://97U4fcebiEixOabl9V…
References (Sources)
- An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function
- Dietary and Microbial Determinants in Food Allergy
- Frontline defenders: goblet cell mediators dictate host-microbe interactions in the intestinal tract during health and disease
- Graft-versus-host disease: Regulation by microbe-associated molecules and innate immune receptors
- Loss of mucosal p32/gC1qR/ HABP1 triggers energy deficiency and impairs goblet cell differentiation in ulcerative colitis
- RELMbeta/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract
- The Role of Fecal Microbiota Transplantation in the Treatment of Acute Graft-versus-Host Disease