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T-bet / T-box transcription factor 21 (TBX21) is a CD4+ Th1 Cells specific transcription factor; however, it is active in many immune cell types but most typically associated with Group 1 ILCs (ILC1) and CD4+ Th1 Cells function
The development of CD4+ Th1 cells relies critically on the activation of Signal transducer and activator of transcription 1 (STAT1) and Signal transducer and activator of transcription 4 (STAT4). These ar…