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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Group 1 ILCs (ILC1)

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When stimulated by intracellular pathogens (e.g., viruses ), Group 1 ILCs (ILC1) help activate macrophages.
Willey et al. 2023 McGraw Hill, USA, ISBN 978-1-265-12303-1

Group 1 ILCs (ILC1) are in general non cytotoxic or only weakly cytotoxic.
Clottu et al. 2022 Front. Immunol. 12: 789788

They express Natural killer cells (NK cells) receptors (NCRs), too. (= NCR+ T-bet+ ILC1). They do not express Eomes and exhibit less cytotoxicity than NK cells
Rickassel et al. 2022 J Immunol 208: 1585-1594

However, Eomesodermin (Eomes) is expressed in intrae…

References (Sources)

Fingolimod Alters Tissue Distribution and Cytokine Production of Human and Murine Innate Lymphoid Cells
Eken et al. 2019 Front. Immunol. 10: 217
Group 1 innate lymphoid cells in Toxoplasma gondii infection
Dunay et al. 2018 Parasite Immunol 40: e12516
Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues
Bernink et al. 2013 Nat Immunol 14: 221-229
ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control
Schwartz et al. 2017 J Exp Med. 214: 2507-21
Innate lymphoid cells: potential targets for cancer therapeutics
Ng & Belz 2023 Trends in Cancer 9(2): 158-171
Review
Regulated expression of nuclear receptor ROR γ t confers distinct functional fates to NK cell receptor-expressing ROR γ t + innate lymphocytes
Vonarbourg et al. 2010a Immunity 33: 736-51
S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense
Huang et al. 2018 Science 359: 114-119

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12/15/2025

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Group 1 ILCs (ILC1)

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