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Group 1 ILCs (ILC1)
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When stimulated by intracellular pathogens (e.g., viruses ), Group 1 ILCs (ILC1) help activate macrophages.
Group 1 ILCs (ILC1) are in general non cytotoxic or only weakly cytotoxic.
They express NK cell receptors (NCRs), too. (= NCR+ T-bet+ ILC1). They do not express Eomes and exhibit less cytotoxicity than NK cells
However, Eomesodermin (Eomes) is expressed in intraepithelial ILC1 (ieILC1) and heterogenous in…
References (Sources)
- Fingolimod Alters Tissue Distribution and Cytokine Production of Human and Murine Innate Lymphoid Cells
- Group 1 innate lymphoid cells in Toxoplasma gondii infection
- Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues
- ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control
- Innate lymphoid cells: potential targets for cancer therapeutics
- Regulated expression of nuclear receptor ROR γ t confers distinct functional fates to NK cell receptor-expressing ROR γ t + innate lymphocytes
- S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense