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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Biological effects / Functions & Propanoate Metabolism / Propionate / Propionic acid

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Contents

Biological effects : Functions & Propionate
GPR41 is expressed in intestinal Enteroendocrine Cells (EEC), stimulating the release of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY). PYY can regulate intestinal movement, aﬀecting the absorption of nutrients in the intestine, and GLP-1 can regulate [satiety](brain://1Kd6g6-650CO1mVpI_…

References (Sources)

Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases
Singh et al. 2010 Journal of Biological Chemistry. 285:27601-27608
Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inﬂammatory responses: a randomised cross-over trial
Chambers et al. 2019 Gut 68: 1430-1438
Eﬀects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults
Chambers et al. 2015 Gut 64: 1744–1754
Metabolism, Potential Applications and Underlying Mechanisms
Al-Lahham et al. 2010 Biochimica et Biophysica Acta 1801: 1175-1183
Review
Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits
De Vadder et al. 2014 Cell 156(1–2): 84-96
The role of short-chain fatty acids in health and disease
Tan et al. 2014 Adv Immunol. 121: 91
The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents
Psichas et al. 2015 Int. J. Obes. 39: 424-429

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