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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Colitis / Intestinal Inflammation & Short-Chain Fatty Acids (SCFAs)

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Intestinally, SCFAs have an anti-inflammatory effect. In colonocytes and macrophages, they inhibit HAC and activate HAT, especially butyrate. This stimulates DNA translation and thus the formation of transcription factors. Inflammatory mediators are downregulat…

Enhanced production of IL-18 in butyrate-treated intestinal epithelium by stimulating of the proximal promoter region.
Kalina et al. 2002 Eur. J. Immunol. 32: 2635–2643
Microbiota-Associated Metabolites and Related Immunoregulation in Colorectal Cancer
Chen & Chen 2021 Cancers 13: 4054
Review
Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
Frank et al. 2007 Proc Natl Acad Sci U S A. 104: 13780–13785
Short chain fatty acids and its producing organisms: An overlooked therapy for IBD?
Deleu et al. 2021 EBioMedicine 66: 103293
Review
Treatment of distal ulcerative colitis with short-chain fatty acid enemas a placebo controlled trial
Scheppach 1996 Dig Dis Sci 41: 2254-2259
Treatment of diversion colitis with short chain-fatty acid irrigation
Harig et al. 1989 N Engl J Med 320: 23-28
Treatment of ulcerative colitis by feeding with germinated barley foodstuff: first report of a multicenter open control trial
Kanauchi et al. 2002 Journal of gastroenterology 37(Suppl 14): 67-72

5/29/2026