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Myeloid cells have the ability to detect microbial signals, which results in changes to their metabolism and epigenetic makeup. This transformation boosts their inflammatory responses when faced with subsequent challenges and offers protection against reinfection by pathogens. This phenomenon is referred to as trained immunity (TI)
A significant portion of gut bacteria communicates with the host's [adaptive immune system](brain://Bhzwgvrt9EeMc20b85fA3g/AcquiredImmuneSystemAdaptiveI…