meRfi®-GM
Gut microbiota & Immunity
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Contents
Myeloid cells have the ability to detect microbial signals, which results in changes to their metabolism and epigenetic makeup. This transformation boosts their inflammatory responses when faced with subsequent challenges and offers protection against reinfection by pathogens. This phenomenon is referred to as trained immunity (TI)
A significant portion of gut bacteria communicates with the host's [adaptive immune system](brain://Bhzwgvrt9EeMc20b85fA3g/AcquiredImmuneSystemAdaptiveI…
References (Sources)
- Friends to remember: innate immune memory regulation by the microbiota
- Infection infidelities drive innate immunity
- Intrahepatic microbes govern liver immunity by programming NKT cells
- Microbial programming of systemic innate immunity and resistance to infection
- The microbiota protects against respiratory infection via GM-CSF signaling
- Thymic development of gut-microbiota-specific T cells
- Trained immunity: general and emerging concepts