meRfi®-GM
Intestinal Stem Cells (ISCs)
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Contents
The accepted model suggests that Lgr5+ crypt-base columnar (CBC) cells cells are the only intestinal stem cell (ISC) compartment. Studies have shown that Lgr5+ cells are not essential for intestinal regeneration. Two main hypotheses arise from this:
- The existence of a quiescent reserve Intestinal Stem Cells (ISCs)
- Differentiated cell plasticity
Findings, supported by in vivo lineage tracing, reveal:
- Lgr5 is not a specific marker for Intestinal Stem Cells (ISCs)
- Stemness potential extends beyond the crypt base to the isthmus region.
- Undifferentiated cells in the isthmus contribute to [intestinal homeostasis](brain://43U2jXbxY0el…
References (Sources)
- Gut microbiota promotes stem cell differentiation through macrophage and mesenchymal niches in early postnatal development
- Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration.
- Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease
- Isolation and characterization of intestinal stem cells based on surface marker combinations and colony-formation assay
- Isthmus progenitor cells contribute to homeostatic cellular turnover and support regeneration following intestinal injury
- Tales from the crypt: new insights into intestinal stem cells
- Time-resolved fate mapping identifies the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells