Colitis / Intestinal Inflammation & Interleukin-23 (IL-23)

Chronic inflammatory disorders such as inflammatory bowel diseases (Crohn’s disease, ulcerative colitis) are caused by lymphocytes that are inappropriately activated and destroy self-tissues. Recent data have assigned a disease-promoting role to Interleukin-23 (IL-23), a cytokine of the Interleukin-12 (IL-12) family
Duerr et al. 2006 Science 314: 1461-1463
Izcue et al. 2009 Annu Rev Immunol 27: 313-338

IL-23 Deficiency or blockade protects from human IBD
Fujino et al. 2003 Gut 52: 65–70
Schmidt et al. 2005 Inflamm. Bowel Dis. 11:16–23
Annunziato et al. 2007
Saruta et al. 2007 Clin. Immunol. 125: 281–90
Fina et al. 2008 Gastroenterology 134: 1038–48
Holtta et al. 2008 Inflamm. Bowel Dis. 14: 1175–84

see also:
Chronic infection
Inflammatory Bowel Disease (IBD) & Interleukin 17 Family / Interleukin-17 (IL-17)