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The gut microbiota induces Interleukin-1 (IL-1) beta (IL-1F2) production in Intestinal mucosal macrophages. This stimulates the production of Interleukin-2 (IL-2) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in ILC3s and their release. This is necessary for regulatory T cells (Tregs) and immunological homeostasis in the [small intestine](bra…