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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Cephalosporins & Clostridioides (Clostridium) difficile

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Cephalosporins, particularly third-generation cephalosporins, are major risk factors for Clostridioides difficile infection (CDI)
Szymczak et al. 2020 Infect Control Hosp Epidemiol. 41(8): 914-920
Sacco et al. 2022 Nature Communications 13: 4370
Merchante et al. 2023 JAC Antimicrob Resist. 5(2): dlad033

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A unique class of Zn2+-binding serine-based PBPs underlies cephalosporin resistance and sporogenesis of Clostridioides difficile
Sacco et al. 2022 Nature Communications 13: 4370
Prescriber perceptions of fluoroquinolones, extended-spectrum cephalosporins, and Clostridioides difficile infection
Szymczak et al. 2020 Infect Control Hosp Epidemiol. 41(8): 914-920
Role of previous systemic antibiotic therapy on the probability of recurrence after an initial episode of Clostridioides difficile infection treated with vancomycin
Merchante et al. 2023 JAC Antimicrob Resist. 5(2): dlad033
Third generation cephalosporins as a risk factor for Clostridium difﬁcile-associated disease: a four-year survey in a general hospital
de Lalla et al. 1989 J Antimicrob Chemother 23: 623-631

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12/16/2025

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Cephalosporins & Clostridioides (Clostridium) difficile

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