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Clostridioides difficile infection (CDI) primarily occurs in patients undergoing antibiotic treatment or chemotherapy (CT), creating an optimal environment for the growth and intestinal colonization of Clostridioides (Clostridium) difficile
Antibiotics reduce the overall diversity of the gut microbiota (dysbiosis), leading to Clostridioides difficile infection (CDI) through the abnormal proliferation of Clostridioides (Clostridium) difficile.
Antibiotic use is one of the major risk factors for C difficile infection, and antibiotic-mediated perturbation of the gut microbiota in those with this infection has been consistently described
Antibiotics directed against Clostridioides (Clostridium) difficile can decrease the load of the pathogen and toxin production
While antibiotics eliminate toxin-producing C. difficile bacteria, they do not affect dormant spores, which can germinate if dysbiosis continues.
see also:
Cephalosporins & Clostridioides (Clostridium) difficile