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Microglia, along with astrocytes, are involved in cholesterol metabolism and transport within the Central Nervous System (CNS). Apolipoprotein E (APOE) is a key player in cholesterol transport and metabolism in the brain.
Apolipoprotein E (APOE) 4 (APOE4) is associated with cholesterol dysregulation in microglia, leading to lipid accumulation and altered inflammatory responses. This dysregulation can contribute to neurodeg…