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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Butyrate / Butyric acid & Intestinal Epithelial Barrier / Mucosal Barrier / Mucus Layer

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Contents

The effects of SCFAs, especially butyrate, on the gut barrier depend on its concentration and the evaluation model used
Liu et al. 2021t European Journal of Nutrition 60: 2317-2330

Butyrate facilitates the maturation of the colonic mucus barrier and counteracts the growth of pathobionts
Zegarra-Ruiz et al. 2019 Cell Host Microbe 25: 113-127.e6
Beaumont et al. 2020 Gut Microbes 11: 1268-1286

Due to the different absorption of [SCFAs](brain://-VvXg…

References (Sources)

A bridge for short‑chain fatty acids to affect inflammatory bowel disease, type 1 diabetes, and non‑alcoholic fatty liver disease positively: by changing gut barrier
Liu et al. 2021t European Journal of Nutrition 60: 2317-2330
Review
A diet-sensitive commensal lactobacillus strain mediates TLR7-dependent systemic autoimmunity
Zegarra-Ruiz et al. 2019 Cell Host Microbe 25: 113-127.e6
Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers
Peng et al. 2009 J Nutr 139(9): 1619-1625
Butyrate: a double-edged sword for health?
Liu et al. 2018d Adv Nutr 9(1): 21-29
Review
Gut microbiota derived metabolites contribute to intestinal barrier maturation at the suckling-to-weaning transition
Beaumont et al. 2020 Gut Microbes 11: 1268-1286
Inhibition of p38 mitogen-activated protein kinase attenuates butyrate-induced intestinal barrier impairment in a Caco-2 cell monolayer model.
Huang et al. 2014 J Pediatr Gastr Nutr 59(2): 264-269
Microbial-derived butyrate promotes epithelial barrier function through IL-10 receptor-dependent repression of claudin-2
Zheng et al. 2017b J. Immunol. 199: 2976-2984

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