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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Butyrate / Butyric acid & Macrophages (CD68s)

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Butyrate / Butyric acid, which is secreted in high amounts by Commensal Bacteria / Commensalism, can modulate the function of Intestinal mucosal macrophages, the most abundant immune cell type in the lamina propria
Chang et al. 2014 Proc. Natl. Acad. Sci. U. S. A. 111: 2247–2252

Treatment of macrophages with Butyrate / Butyric acid led to the downregulation of lipopolysaccharide-induced [pro-inflammatory mediators](bra…

Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis
Singh et al. 2014 Immunity 40: 128-139
Butyrate affects differentiation, maturation and function of human monocyte-derived dendritic cells and macrophages
Millard et al. 2002 Clin Exp Immunol. 130: 245-255
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
Koh et al. 2016 Cell 165: 1332
Review
Microbiota metabolite short-chain fatty acids (SCAFs), GPCR, and inﬂammatory bowel diseases
Sun et al. 2017
The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition
Chang et al. 2014 Proc. Natl. Acad. Sci. U. S. A. 111: 2247–2252
The short chain fatty acid butyrate imprints an antimicrobial program in macrophages
Schulthess et al. 2019 Immunity 50: 432-445

5/29/2026