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The Tryptophan metabolite indole-3-propionic acid (IPA) plays a significant role in enhancing the efficacy of immunotherapy across various cancer mouse models, such as melanoma, breast cancer, and colorectal cancer. Interestingly, IPA is produced through a synergistic interaction between Lactobacillus johnsonii and [Clostridium sporogenes](brain://ldljgwfD…