meRfi®-GM
Indole-3-propionic acid / Indole-3-Propionate (IPA)
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The Tryptophan metabolite indole-3-propionic acid (IPA) plays a significant role in enhancing the efficacy of immunotherapy across various cancer mouse models, such as melanoma, breast cancer, and colorectal cancer. Interestingly, IPA is produced through a synergistic interaction between Lactobacillus johnsonii and [Clostridium sporogenes](brain://ldljgwfD…
References (Sources)
- A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites
- Circulating levels of the anti-oxidant indoleproprionic acid are associated with higher gut microbiome diversity
- Indole-3-Propionic Acid, a tryptophan-derived bacterial metabolite, reduces weight gain in rats
- Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study
- Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer
- Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4
- The gut metabolite indole-3 propionate promotes nerve regeneration and repair