CD4+ CD25++ FOXP3 low nTreg / tTreg

• Origin: Thymus


• Markers: CD4 +, CD25 high, CD62L +, CTLA-4 -, FOXP3 low, CD45RA +, CD45RO -, HLA-DR -, CD95 -

The thymus-derived CD4+ CD25 high FOXP3 low nTreg / tTreg are thought to be ‘natural’ Treg cells

Originate in the thymus and emigrate as naive CD45RA+ T cells into the periphery
Sakaguchi et al. 2010 Nature 10: 490
Maslanka et al. 2017 PloS One 12(1): e0170021

Thymic Tregs (tTregs, also nTregs) derive from thymocytes and are educated against self-antigen
Josefowicz et al. 2012 Annu Rev Immunol 30: 531-564

Tregs develop in the thymus and migrate to the periphery, called natural Tregs
Koch et al., 2008

CD28 costimulation of developing thymocytes induces Foxp3 expression and Treg differentiation independently of IL-2
Tai et al. 2005