meRfi®-GM
CD4+ CD25++ FOXP3 low nTreg / tTreg
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Contents
- Origin: Thymus
- Markers: CD4 +, CD25 high, CD62L +, CTLA-4 -, FOXP3 low, CD45RA +, CD45RO -, HLA-DR -, CD95 -
The thymus-derived CD4+ CD25 high FOXP3 low nTreg / tTreg are thought to be ‘natural’ Treg cells
Originate in the thymus and emigrate as naive CD45RA+ T cells into the periphery
Thymic Tregs (tTregs, also nTregs) derive from thymocytes and are educated against self-antigen
Tregs develop in the thymus and migrate to the periphery, c…
References (Sources)
- Alloantigen-induced regulatory CD8+ CD103+ T cells
- CD25+CD127 +Foxp3- Cells Represent a Major Subpopulation of CD8+ T Cells in the Eye Chambers of Normal Mice
- CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2
- FOXP3 + regulatory T cells in the human immune system
- Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells
- Regulatory T cells: mechanisms of differentiation and function