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NF kappa B (NFKB) / NFKB Family is a stimulus-responsive inducible transcription factor with cytoplasmic localization in the steady state. A reasonable proxy for NFKB activation in live cells is the relative nuclear concentration (i.e., the ratio of nuclear to total cellular concentration), where it binds to transcription genes
Context-specific induction of other NF kappa B (NFKB) factors also tune inflammatory genes
Mainly RelA:p50 , induced by the canonical NFKB Signal transduction / NFKB Signal transduction pathway , activates inflammatory genes
The activated NF kappa B (NFKB) is transferred to the nucleus and promotes the expression of genes encoding pro-inflammatory cytokines (inflammatory genes), such as TNF-alpha, IL-1beta, and IL-6. IL-6 can activate the JAK-STAT Signaling Pathway, leading to reduced apoptosis and HCC progression
The classic form of NF kappa B (NFKB) / NFKB Family is the heterodimer of the p65/RelA and p50 subunits
It is activated in response to various stimuli, including LPS, TNF-alfa, double-stranded RNA, and ultra-violet radiation
NF kappa B (NFKB) / NFKB Family signaling can be inhibited by Curcumin.
Feudlsperger et al. 2008