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Growth/differentiation factor 15 (GDF15) can suppress a type 1 and, in contrast, promote a type 2 inflammatory response
Inflammation, a major factor in many diseases, is mediated by endothelial cells in blood vessels
Drive the induction of autoreactive T cells, in particular IL-17-producing gamma-delta T cells and CD4+ Th17 cells
see also:
Inflammation / Inflammatory diseases