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The organization of the glycosylation machinery within the Goblet cell is depicted.
N-glycan addition in goblet cells is crucial for proper MUCIN-2 (MUC2) production because it ensures correct mucin folding, maturation, and secretion. Without N-glycans, MUCIN-2 (MUC2) cannot form the necessary dimers and oligomers, which are critical for its function as a gel-forming mucin
Sun et al. 2023 Molecules …