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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Flagellin

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Flagellin is a structural component of bacterial flagella produced by pathogenic, symbiotic, and neutral bacteria

Silent flagellin proteins were present in human stool. These silent flagellins were mainly produced by the abundant gut bacteria Lachnospiraceae.
Clasen et al. 2023 Science Immunology 8(79): https://doi.org/10.1126/sciimmunol.abq7001

Flagellins from commensals can be tolerated by the host, while those from pathobionts can trigger reactions in the host.
Clasen et al. 2023 Science Immunology 8(79): https://doi.org/10.1126/sciimmunol.abq7001

Flagellin and Anti-CD3 monoclonal antibody, two di…

References (Sources)

Bacterial flagellin is a dominant antigen in Crohn disease
Lodes et al. 2004 J Clin Invest 113(9): 1296-306
Extraction of Peptidoglycan from L. paracasei subp. Paracasei X12 and Its Preliminary Mechanisms of Inducing Immunogenic Cell Death in HT-29 Cells
Tian et al. 2015
Flagellin stimulation of intestinal epithelial cells triggers CCL20-mediated migration of dendritic cells
Sierro et al. 2001 Proc Natl Acad Sci USA 98: 13722-13727
Integrative inﬂammasome activity in the regulation of intestinal mucosal immune responses
Elinav et al. 2013
Review
Mo1795 dietary treatment of Crohn’s disease: a randomized, placebo-controlled, double-blinded clinical trial
Mutlu et al. 2016 Gastroenterology 150(4, Supplement 1): S778
The struggle within: microbial inﬂuences on colorectal cancer
Arthur et al. 2011
Toll-like receptor signaling in colorectal cancer: carcinogenesis to cancer therapy
Li et al. 2014b

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Flagellin - Wikipedia
https://doi.org/10.1126/sciimmunol.abq7001
https://doi.org/10.1126/sciimmunol.abq7001