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Flagellin

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Flagellin is a structural component of bacterial flagella produced by pathogenic, symbiotic, and neutral bacteria

Silent flagellin proteins were present in human stool. These silent flagellins were mainly produced by the abundant gut bacteria Lachnospiraceae.
Clasen et al. 2023 Science Immunology 8(79): https://doi.org/10.1126/sciimmunol.abq7001

Flagellins from commensals can be tolerated by the host, while those from pathobionts can trigger reactions in the host.
Clasen et al. 2023 Science Immunology 8(79): https://doi.org/10.1126/sciimmunol.abq7001

Flagellin and Anti-CD3 monoclonal antibody, two di…