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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Candidatus Savagella (Segmented filamentous bacteria/SFB)

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Candidatus Savagella (Segmented filamentous bacteria/SFB) adheres to epithelial cells in the ileum. It induces CD4+ Th17 cells. These cells express Interleukin-17A (IL-17A), Interleukin-17F (IL-17F), Interleukin-22 (IL-22), and Interleukin-10 (IL-10). They protect the epithelial barrier
Yang et al. 2014 Nature 510: 152-156
Aschenbrenner et al. 2018 Nat Immun…

‘Candidatus Arthromitus’ revised: segmented filamentous bacteria in arthropod guts are members of Lachnospiraceae
Thompson et al. 2012 Environ. Microbiol. 14: 1454-1465
Dysbiosis and the immune system
Levy et al. 2017
Review
Focused specificity of intestinal TH17 cells towards commensal bacterial antigens
Yang et al. 2014 Nature 510: 152-156
Induction of intestinal Th17 cells by segmented filamentous bacteria
Ivanov et al. 2009
Segmented filamentous bacteria take the stage
Ivanov & Littman 2010 Mucosal Immunol. 3: 209-212
Segmented filamentous bacteria: commensal microbes with potential effects on research
Ericsson et al. 2014 Comp Med. 64: 90-98
Th17 cell induction by adhesion of microbes to intestinal epithelial cells
Atarashi et al. 2015 Cell 163(2): 367–80

12/16/2025