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The microbiota present in the mesenteric adipose tissue of individuals with Crohn's disease can induce colitis in mice. The key pathogens Achromobacter pulmonis and Klebsiella variicola are responsible for the exacerbation of colitis. The mesenteric adipose tissue-derived bacterium, Klebsiella variicola, disrupts the intestinal barrier and promotes colitis through the [Type VI secretion system](brain://G3mjfRHmS0WM5kGP6HnP6A/TypeViSe…