meRfi®-GM
Immune tolerance
Welcome to meRfi-GM!
meRfi-GM provides you with up-to-date, evidence-based insights on the gut microbiota and related health topics.
Access our ever-expanding digital library and get personalized answers through our interactive AI chat platform.
Start your free trial and transform your understanding of the gut microbiota today!
Navigation
Contents
Activated T cells expressing IL-2 receptor a-chains (CD25) (i.e., Regulatory T Cells (Tregs)) maintain immunologic self-tolerance. Among the key mechanisms of Immune tolerance, recent studies have identified that regulatory T cells (Tregs) are crucial in sustaining self-tolerance and immune homeostasis. They achieve this by suppressing a wide range of physiological and pathological immune responses against self, nonself, and quasi-self tumor antigens. The most physiologically relevant Treg population is [CD25+ CD4+ Treg](brain://XN2yru…
References (Sources)
- An essential role for Scurfin in CD4 + CD25 + T regulatory cells
- CD4+ CD25+ suppressor T cells: more questions than answers
- Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor a-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
- Regulatory T cells in tumor immunity
- Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
- Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease
- Tolerance in the Age of Immunotherapy