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Activated T cells expressing IL-2 receptor a-chains (CD25) (i.e., Regulatory T Cells (Tregs)) maintain immunologic self-tolerance. Among the key mechanisms of Immune tolerance, recent studies have identified that regulatory T cells (Tregs) are crucial in sustaining self-tolerance and immune homeostasis. They achieve this by suppressing a wide range of physiological and pathological immune responses against self, nonself, and quasi-self tumor antigens. The most physiologically relevant Treg population is [CD25+ CD4+ Treg](brain://XN2yru…