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Tolerogenic dendritic cells (tolDCs)
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Contents
Tolerogenic DCs (tolDCs) are functionally defined by their ability to expand the regulatory T-cell compartment and suppress immune responses. However, it remains unclear whether tolDCs represent:
- A homogeneous population
- A specific DC subset
- A heterogeneous collection of DC activation/maturation states
The ligand-activated transcription factor aryl hydrocarbon receptor (AHR) has been shown to control transcriptional programs associated with Tolerogenic dendritic cells (tolDCs).
Tolerogenic are heterogenous pool of DC with immuno-suppressive properties. Tolerogenic dendritic cells (tolDCs) show reduced expression of [costimulatory molecules](brain://1IgnuS2kNl-fJUUVbifSqg/CostimulatoryMolecu…