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Aryl Hydrocarbon Receptor (AhR)
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Contents
The Aryl Hydrocarbon Receptor (AhR) is a ligand-activated transcription factor that plays a crucial role in modulating intestinal immune responses (1). AhR induces its negative regulator, the AHR repressor (AHRR), which is vital for sustaining intestinal intraepithelial lymphocytes (IELs) (1).
References:
(1)
The aryl hydrocarbon receptor acts as a mediator in the interaction between the host and microbiota.
Situated in the cytoplasm in an inactive complex, Aryl Hydrocarbon Receptor (AhR) translocates into the nucleus upon ligand bin…
References (Sources)
- Ah receptor signaling pathways
- Cell-intrinsic view of the aryl hydrocarbon receptor in tumor immunity
- Feedback control of AHR signalling regulates intestinal immunity
- Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor
- The aryl hydrocarbon receptor: a perspective on potential roles in the immune system
- The aryl hydrocarbon receptor: Multitasking in the immune system
- The PAS superfamily: sensors of environmental and developmental signals