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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Caspase-8 & Immunity

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The influence of caspase-8 on immune responses is essentially based on its mechanism of triggering cell death in cells.

Caspase-8 auto-cleavage regulates programmed cell death and collaborates with RIPK3/MLKL to prevent lymphopenia
Li et al. 2022v Cell Death Differ 29: 1500-1512
Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis
Fritsch et al. 2019 Nature 575: 683–687
Caspase-8 protein cuts a brake on immune defences
Brodsky 2020
Caspase-8: regulating life and death
Tummers & Green 2017 Immunol Rev. 277(1): 76-89
Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity
Salmena et al. 2003 Genes Dev. 17(7): 883-95
Multiple roles of caspase-8 in cell death, inflammation, and innate immunity
Orning & Lien 2021 J Leukoc Biol. 109(1): 121-141
Novel roles for caspase-8 in IL-1β and inflammasome regulation
Gurung & Kanneganti 2015 Am J Pathol. 185(1): 17-25
Review

2/27/2026