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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Caspase-8 & Pyroptosis

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After activation of caspase-8, for example, by Tumor Necrosis Factor alfa (TNF-alfa), Caspase-8 can directly cleave gasdermin D (GSDMD) under certain conditions, triggering pyroptosis.

The pro-inflammatory cytokine interleukin-1beta is released.

Demarco et al. 2020 Sci Adv. 6(47): eabc3465
Yu et al. 2021e Sig Transduct Target Ther 6: 128
Zhang et al. 2021 Cell Res 31: 980-997
Wei et al…

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis
Fritsch et al. 2019 Nature 575: 683–687
Caspase-8-dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality
Demarco et al. 2020 Sci Adv. 6(47): eabc3465
Pyroptosis: mechanisms and diseases
Yu et al. 2021e Sig Transduct Target Ther 6: 128
Review
Role of pyroptosis in inflammation and cancer
Wei et al. 2022a Cell Mol Immunol 19: 971-992
Review
The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8
Zhang et al. 2021aa Cell Res 31: 980-997
The role of caspase-8 in inflammatory signalling and pyroptotic cell death
Pang & Vince 2023 Semin Immunol. 70: 101832

2/27/2026