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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Inflammation / Inflammatory Diseases & Polyamines / Polyamine

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Polyamines Perform Anti-inﬂammatory Functions
Chen & Chen 2021 Cancers 13: 4054

Polyamines downregulated LPS-induced IL-1 and IFN-gamma, upregulated the production of IL-10 in macrophages, and suppressed the activation of pro-inﬂammatory M1 macrophages
Hasko et al. 2000 Shock 14: 144–…

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Microbiota-Associated Metabolites and Related Immunoregulation in Colorectal Cancer
Chen & Chen 2021 Cancers 13: 4054
Review
Ornithine decarboxylase regulates M1 macrophage activation and mucosal inﬂammation via histone modiﬁcations
Hardbower et al. 2017 Proc. Natl. Acad. Sci. USA 114: E751–E760
Spermine differentially regulates the production of interleukin-12 p40 and interleukin-10 and suppresses the release of the T helper 1 cytokine interferon-gamma
Hasko et al. 2000 Shock 14: 144–149

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12/16/2025

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Inflammation / Inflammatory Diseases & Polyamines / Polyamine

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