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The IL-12B subunit, also known as IL-12p40, is a component of the interleukin-12 (IL-12) family of cytokines. It is one of the two subunits that make up the heterodimeric cytokine IL-12, the other being IL-12p35 (IL-12A). IL-12 is produced by activated macrophages and is involved in the differentiation of naive T cells into Th1 cells, which are important for the immune response against intracellular pathogens
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