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Creeping fat (CrF) is linked to surgical recurrence in Crohn’s disease.
Metabolome analysis shows L-kynurenine is enriched in Creeping Fat (CrF). Indoleamine 2,3-Dioxygenase (IDO) upregulation boosts kynurenine metabolism. This drives mesenteric adipogenesis.
L-kynurenine-induced adipogenesis is mediated by aryl hydrocarbon receptors. IDO1 (indoleamine 2,3-dioxygenase1) inhibitors or bacteria degrading L-kynurenine reduce adipogenesis in mice
Hyperplasia and migration of mesenteric fat tissue are known as Creeping Fat (CrF). This is an extraintestinal manifestation of Crohn's disease (CD). CrF surrounds inflammation sites in the intestine, especially in the terminal ileum. Although CrF can limit the spread of inflammation, it is associated with complications such as intestinal fibrosis and strictures. Involvement of the mesentery in resection reduces surgical recurrence. The mechanism of CrF formation is still unclear.
Ectopic bacteria can alter local adipose tissue, exacerbating systemic inflammatory and metabolic diseases. Studies show that increased gut permeability leads to the translocation of microbiota, contributing to the formation of creeping fat (CrF). This underscores the role of microbiota in the reconstruction of CrF. Targeted interventions in microbiota-induced changes could offer a therapeutic strategy for the progression of Crohn's disease (CD)
Succinate promotes adipose tissues browning in Crohn's disease (CD)
see also:
Colitis / Intestinal inflammation