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Biological effects / Functions & Succinate / Succinic acid
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Succinate / Succinic acid in the intestinal lumen plays a crucial role in immune response and cellular differentiation. Here is a detailed breakdown of its functions and interactions:
- Succinate / Succinic acid triggers the production of Interleukin-25 (IL-25) by chemosensory tuft cells.
- Interleukin-17E (IL-17E) / Interleukin-25 (IL-25) activates the expression of Interleukin-13 (IL-13) by [Group 2 Innate Lymphoid Cells (ILC2)](brain://RntRt…
References (Sources)
- A metabolite-triggered tuft cell-ILC2 circuit drives small intestinal remodeling.
- Detection of succinate by intestinal tuft cells triggers a type 2 innate immune circuit.
- Microbiota-produced succinate improves glucose homeostasis via intestinal gluconeogenesis
- Sense and immuno-sensibility: innate lymphoid cell niches and circuitsReview
- The Gut Microbiota Metabolite Succinate Promotes Adipose Tissue Browning in Crohn’s Disease