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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Biological effects / Functions & Succinate / Succinic acid

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Succinate / Succinic acid in the intestinal lumen plays a crucial role in immune response and cellular differentiation. Here is a detailed breakdown of its functions and interactions:

Succinate / Succinic acid triggers the production of Interleukin-25 (IL-25) by chemosensory tuft cells.

Interleukin-17E (IL-17E) / Interleukin-25 (IL-25) activates the expression of Interleukin-13 (IL-13) by [Group 2 Innate Lymphoid Cells (ILC2)](brain://RntRt…

References (Sources)

A metabolite-triggered tuft cell-ILC2 circuit drives small intestinal remodeling.
Schneider et al. 2018 Cell 174: 271-284
Detection of succinate by intestinal tuft cells triggers a type 2 innate immune circuit.
Nadjsombati et al. 2018 Immunity 49: 33-41
Microbiota-produced succinate improves glucose homeostasis via intestinal gluconeogenesis
De Vadder et al. 2016 Cell Metab 24: 151-157
Sense and immuno-sensibility: innate lymphoid cell niches and circuits
McFarland & Colonna 2020
Review
The Gut Microbiota Metabolite Succinate Promotes Adipose Tissue Browning in Crohn’s Disease
Monfort-Ferré et al. 2022 J Crohns Colitis 16: 1571-1583

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12/16/2025

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Biological effects / Functions & Succinate / Succinic acid

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