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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Histone Deacetylase (HDAC) inhibition

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When Histone Deacetylase (HDAC) activity is inhibited, the level of suppressor chromosome rises, thus regulating the expression of epigenetic genes
Kaisar et al. 2017 Front Immunol 8: 1429

Inhibition of histone deacetylases (HDAC) activity mainly by butyrate and propionate
Sun et al. 2017

Histone Deacetylase (HDAC) inhibition affects the expression of only 2% of mammalian genes
Davie et al. 2003 J Nutr 133 (7, Suppl):2485S–2493S.

see also:
[Butyrate / Butyric acid & Histone Deacetylase (HDAC) inhibition](brain://ULn6CJnYO06QjXjgG4Bf9w/ButyrateButyricAcidHisto…

References (Sources)

Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases
Singh et al. 2010 Journal of Biological Chemistry. 285:27601-27608
Butyrate conditions human Dendritic cells to Prime Type 1 regulatory T cells via both histone Deacetylase inhibition and G Protein-coupled receptor 109A signaling
Kaisar et al. 2017 Front Immunol 8: 1429
Butyrate decreases its own oxidation in colorectal cancer cells through inhibition of histone deacetylases
Han et al. 2018a
Inhibition of histone deacetylase activity by butyrate
Davie et al. 2003 J Nutr 133 (7, Suppl):2485S–2493S.
Review
Microbiota metabolite short-chain fatty acids (SCAFs), GPCR, and inﬂammatory bowel diseases
Sun et al. 2017
Reolysin and Histone Deacetylase Inhibition in the Treatment of Head and Neck Squamous Cell Carcinoma
Jaime-Ramirez et al. 2017
The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition
Chang et al. 2014 Proc. Natl. Acad. Sci. U. S. A. 111: 2247–2252

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