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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Histone Deacetylase (HDAC) inhibition

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When Histone Deacetylase (HDAC) activity is inhibited, the level of suppressor chromosome rises, thus regulating the expression of epigenetic genes
Kaisar et al. 2017 Front Immunol 8: 1429

Inhibition of histone deacetylases (HDAC) activity mainly by butyrate and propionate
Sun et al. 2017

Histone Deacetylase (HDAC) inhibition affects the expression of only 2% of mammalian genes
Davie et al. 2003 J Nutr 133 (7, Suppl):2485S–2493S.

see also:
Butyrate / Butyric acid & Histone Deacetylase (HDAC) inhibition
Butyrate / Butyric acid & Trichostatin A (TSA)
Histone Deacetylase (HDAC) Inhibition & Propanoate Metabolism / Propionate / Propionic acid

References (Sources)

Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases
Singh et al. 2010 Journal of Biological Chemistry. 285:27601-27608
Butyrate conditions human Dendritic cells to Prime Type 1 regulatory T cells via both histone Deacetylase inhibition and G Protein-coupled receptor 109A signaling
Kaisar et al. 2017 Front Immunol 8: 1429
Butyrate decreases its own oxidation in colorectal cancer cells through inhibition of histone deacetylases
Han et al. 2018a
Histone deacetylase inhibition accelerates the early events of stem cell differentiation: transcriptomic and epigenetic analysis
Karantzali et al. 2008 Genome Biol 9(4): R65
Inhibition of histone deacetylase activity by butyrate
Davie et al. 2003 J Nutr 133 (7, Suppl):2485S–2493S.
Review
Microbiota metabolite short-chain fatty acids (SCAFs), GPCR, and inﬂammatory bowel diseases
Sun et al. 2017
Reolysin and Histone Deacetylase Inhibition in the Treatment of Head and Neck Squamous Cell Carcinoma
Jaime-Ramirez et al. 2017
Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
Cameron et al. 1999
The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition
Chang et al. 2014 Proc. Natl. Acad. Sci. U. S. A. 111: 2247–2252

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