Metabolic Syndrome (MetS)

Metabolic Syndrome means at least three of the five following medical conditions: abdominal adiposity / obesity, high blood pressure, high blood sugar, high serum triglycerides, and low serum High-density lipoprotein (HDL)). High blood sugar and adiposity are part of Metabolic syndrome (about 24% of adults harbor it).

In Mexico, a statement in 2020 revealed that 43% of deaths were attributed to diseases related to MetS.
INEGI 2021 Comunicado de prensa núm. 61/21 de enero de 2021

Obesity, hyperglycemia, dyslipidemia, and hypertension are the primary risk factors for Metabolic Syndrome (MetS)
Oda 2018 Clin Dermatol 36: 3-8

If these factors are not addressed comprehensively, it eventually leads to the development of cardiovascular disease, metabolic disease, cerebrovascular disease, and chronic inflammation.
Castro-Barquero et al. 2020 Nutrients 12: 2983

High consumption of large amounts of saturated fat and Carbohydrates / Saccharides is the main predisposing factor for Metabolic Syndrome (MetS).
Hannou et al. 2018 J. Clin. Invest. 128: 545-555

Metabolic syndrome is a multifaceted and significant issue in global public health. Its emergence is linked to the adoption of Western dietary and lifestyle habits. The World Health Organization (WHO) reported that MetS was the cause of 41 million deaths, accounting for 71% of the 57 million deaths worldwide in 2016. The global prevalence of MetS continues to rise across all ages, genders, and cultures

A high-fat diet favors the development of the typical conditions of a metabolic syndrome. The high-fat diet triggers dysbiosis (lower diversity of the gut microbiota) and thus also a changed microbiota-dependent bile acid metabolism. The gut microbiota and the farnesoid X receptor axis play a role in modulating metabolic disease. Antagonists at the intestinal FXR receptor or its ablation prevent the development of MetS in mice.
Jiang et al. 2015a
Jiang et al. 2015 Nat Commun 6: 10166
Gonzalez et al. 2016 Gastroenterology 151: 845-59

Metabolic syndrome (MetS) and depression are among the most common and debilitating disorders worldwide
Marazziti et al. 2014 CNS Spectr. 19: 293-304

Metabolic syndrome is a set of conditions that increase the risk of cardiovascular disease.
Vulevic et al. 2013 J. Nutr. 143: 324–331

see also:
Adiposity / Obesity
Adiposity / Obesity & Farnesoid X Receptor (FXR / NR1H4)
Farnesoid X receptor (FXR / NR1H4)
Food / Diets / Nutrients & Metabolic Syndrome (MetS)
Metabolic syndrome (MetS) type II
Western Diet (WD) / Western Pattern Diet
White Adipose Tissue (WAT)