Loading…
Microbial metabolismregulates circulating nutrients and hormones, such as leptin, insulin, and glucagon-like peptide 1, that affect neural circuits underlying hunger and satiety
High-fat diet administered to mice leads to an increase in Firmicutes (phylum level), Lachnospiraceae (family level), and Streptococcaceae (family level) associated with an increase in plasma leptin, Tumor Necrosis Factor alfa (TNF-alfa), Interleukin-6 (IL-6)
The abundance of Akkermansia muciniphila shows a positive correlation with the lipid metabolism, and an inverse correlation with lipid synthesis, inflammatory markers (i.e., insulin, leptin, glucose and triglycerides) and several serum markers of insulin resistance, cardiovascular risk and adiposity
A significant positive correlation between the quantity of Bifidobacterium and Lactobacillus and serum leptin levels, and a significant and negative correlation among the number of Clostridium, Bacteroides and Prevotella and serum leptin levels in all experimental groups (male rats)
The first link between gut microbial environment and obesity was hypothesized by Ley et al. that analyzed the gut microbiota of leptin -deficient mice at major phyla level
see also:
Akkermansia muciniphila MucT TM & Adiposity / Obesity
Akkermansia muciniphila & Adiposity / Obesity