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Lithocholic acid (LCA) feeding resulted in severe liver damage and activation of the NLRP3 inflammasome
Kupffer cells (KC) were the most affected cells, resulting in a pro-inflammatory phenotype .
Lithocholic acid (LCA) is the main bile acid ligand for the pregnane X receptor, Vitamin D receptor (VDR) is activated by LCA, but not by other [Bile acids / Bile salts](brain://7ZdBK_faqEi6LCdQO4CGnQ/BileAcidsBi…