meRfi®-GM
The Digital Textbook on Gut Microbiota and Beyond
Low-grade Chronic Inflammation (inflammaging)
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Contents
Although the exact mechanisms remain unclear, the aberrant elevation of reactive oxygen and nitrogen species (RONS) levels from several endogenous and exogenous processes in the brain may affect cell signaling and trigger cellular senescence inflammation and pyroptosis.
Onyango et al. 2021 Biomedicines 9: 524
These are reflected by changes in circulating immune markers, including C-reactive protein (CRP) [26], interleukin-6 (IL-6) [27], tumor necrosis factor-alpha ([TNF-α](…
References (Sources)
- Age-related cerebral small vessel disease and inflammaging
- Fueling Inflamm-Aging through Mitochondrial Dysfunction: Mechanisms and Molecular Targets
- Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?
- Inflamm-aging: An evolutionary perspective on immunosenescence
- Meta-inflammaging at the crossroad of geroscience
- Mitochondria, immunosenescence and inflammaging: A role for mitokines?
- Pro-inflammatory cytokine 11 plays a pivotal role in inflammaging-associated pathologies