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Although the exact mechanisms remain unclear, the aberrant elevation of reactive oxygen and nitrogen species (RONS) levels from several endogenous and exogenous processes in the brain may affect cell signaling and trigger cellular senescence inflammation and pyroptosis.
Onyango et al. 2021 Biomedicines 9: 524
These are reflected by changes in circulating immune markers, including C-reactive protein (CRP) [26], interleukin-6 (IL-6) [27], tumor necrosis factor-alpha ([TNF-α](…