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Mucosal-associated invariant T (MAIT) cells are predominantly found in barrier tissues such as the lung, liver, skin, and colon. These cells recognize metabolites derived from the Biosynthesis & Vitamin B2 (riboflavin) pathway. They can rapidly traverse epithelial barriers and are presented during MAIT cell differentiation in the thymus and maturation in peripheral tissues. Additionally, microbial metabolites significantly influence the functions of MAIT cells under various conditions,…