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The ubiquitin system serves protein modification and thereby regulates many essential cellular processes. An example is the induced endothelial dysfunction. It plays a crucial role in the pathophysiology of sepsis and organ failure. The underlying cause of sepsis is the host's overwhelming inflammatory response to the pathogen infection, leading to endothelial dysfunction. As the key factors of the ubiquitin system, E3 ligases are at the center of the battle between host and microbial pathogens. Such diversity of ubiquitination regulates a variety of cellular regulatory processes, including signal transduction, autophagy, inflammasome activation, redox reaction, immune response, and so on.
Ubiquitin Serves as a Signal not only for the Proteasome but also for Macroautophagy
Ubiquitination regulates NFKB activation and inhibition. IkB family is ubiquitinated