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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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G-Protein Coupled Receptor 43 (GPR43) & Propanoate Metabolism / Propionate / Propionic acid

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GPR41 was expressed primarily in adipose tissue, whereas the highest levels of GPR43 were found in immune cells. The identity of the cognate physiological ligands for these receptors is not clear, although propionate is known to occur in vivo at high concentrations under certain pathophysiological conditions
Brown et al. 2003 J. Biol. Chem. 278: 11312-11319

see also:
[Enterocytes / Intestinal Epithelial Cells (IECs) & Short-Chain Fatty Acids (S…

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The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids
Brown et al. 2003 J. Biol. Chem. 278: 11312-11319

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12/16/2025

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G-Protein Coupled Receptor 43 (GPR43) & Propanoate Metabolism / Propionate / Propionic acid

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