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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

G-protein coupled receptor 183 (GPR183) & Inflammatory Bowel Disease (IBD)

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A single-nucleotide polymorphism in G-protein coupled receptor 183 (GPR183) has been linked to increased risk for ulcerative colitis and Crohn’s disease
Jostins et al. 2012 Nature 491: 119-124
Ruiz et al. 2021 Br. J. Pharmacol. 178: 3157-3175

Oxysterol recognition by G-protein coupled receptor 183 (GPR183) promotes lymphoid tissue-inducing function of innate lymphoid cells and [intestinal inflammation](brain://BzW6blFRg06hY4CJBJgUKA/ColitisIntesti…

A single nucleotide polymorphism in the gene for GPR183 increases its surface expression on blood lymphocytes of patients with inflammatory bowel disease
Ruiz et al. 2021 Br. J. Pharmacol. 178: 3157-3175
Activation of the liver X receptor protects against hepatic injury in endotoxemia by suppressing Kupffer cell activation
Wang et al. 2006 Shock 25: 141-146
Expression of SREBP-1c requires SREBP-2-mediated generation of a sterol ligand for LXR in livers of mice
Rong et al. 2017 eLife 6: e25015
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Jostins et al. 2012 Nature 491: 119-124
Oxysterol sensing through the receptor GPR183 promotes the lymphoid-tissue-inducing function of innate lymphoid cells and colonic inflammation
Emgard et al. 2018 Immunity 48: 120-132
The EBI2-oxysterol axis promotes the development of intestinal lymphoid structures and colitis
Wyss et al. 2019 Mucosal Immunol. 12: 733-745

2/27/2026